SEMA3C Supports Pancreatic Cancer Progression by Regulating the Autophagy Process and Tumor Immune Microenvironment

To date, driver genes for pancreatic cancer treatment are difficult to pursue therapeutically.Targeting mutated KRAS, the most renowned driver gene in pancreatic cancer, is an active area of study.We discovered a gene named SEMA3C was highly expressed in pancreatic cancer cell lines and patients with a G12D mutation in KRAS.High expression of SEMA3

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Monitoring Dynamic Changes of Cellular Membrane GSH During Stroke via an ESIPT-Based Near-Infrared Fluorescent Probe

Stroke, primarily ischemic (85%), results from inadequate blood supply and is worsened by ferroptosis, characterized by free radical generation Vacuum Cloth Filter and lipid peroxidation.Monitoring ferroptosis is essential for understanding its mechanisms and developing treatments.Glutathione (GSH) is a key ferroptosis biomarker, but current probes

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Gut microbiota determines the social behavior of mice and induces metabolic and inflammatory changes in their adipose tissue

Abstract The link between the gut microbiota and social behavior has been demonstrated, however the translational impact of a certain microbiota composition on stable behavioral patterns is yet to be elucidated.Here we employed an established social behavior mouse model of dominance (Dom) or submissiveness (Sub).A comprehensive 16S rRNA gene sequen

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